pentobarbital will lessen the extent or influence of ambrisentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of CYP3A4 inducers might lesse